Home > Shop by Skin Concern > Serums
Store shelves are lined from floor to ceiling with moisturizer options. How can you know which type of product — lotion, cream or serum — is right for you? Learn more about these products, so you can find the best skin care for you.

Lotions, creams and serums may contain humectants to moisturize and hydrate, as well as emollients to help seal in moisture and protect your skin. One of the biggest distinctions between these three is consistency.

Lotions are usually thinner in texture, because they contain greater amounts of water than oil. Creams, however, are oil-based and thick, containing deeply moisturizing ingredients. Serums are water-based, designed to be used in conjunction with both lotions and creams. And although they offer incredible benefits to the skin, serums are generally optional.


Because lotions are lightweight and made with minimum amounts of oil, they’re ideal for normal to oily skin. Drier skin types typically require more hydration. Lotions get absorbed quickly and can be used day and night. You’ll find a wide array of formulas.


Because of their thick and rich consistency, creams provide dry and sensitive skin with extra moisture. Moisturizing creams contain many healing ingredients, including oils, plant extracts, hydrators and humectants, and they provide the skin with a protective layer, sealing in moisture and fending off environmental damage. They also give skin a smooth, velvety appearance and certain anti-aging creams will even improve the depth of fine lines.

Cream is also beneficial for combination skin that shows a slight shine during the day but requires more moisture than a lotion can provide. Use cream sparingly or strictly on the driest parts of your skin (such as the cheeks and neck).


One of the biggest benefits of serums is that they’re designed to penetrate deeper into the skin. They contain less “oils, wax and heavy lipids,” and are lighter, according to Daniel Maes, Ph.D., vice president of research and development at Estée Lauder, in Notebook. In addition, serums deliver high concentrations of skin-nourishing ingredients.

Bottom line

Many people find that with seasonal changes they need to switch moisturizers. For instance, normal skin can get oily during the summer (thereby needing a lighter moisturizer) but might need extra hydration in the winter (from a cream).

You might want to consult a skin care specialist about which combination of products is best to use. For example, some moisturizers can hamper the effectiveness of serums. “In the case of products formulated with alpha and beta hydroxy acids, the oils used in creams and lotions can interfere with the acidity of the active ingredients, making them less effective,” dermatologist Natasha Cook, M.D., tells Notebook.

Sort By:
Page of 2
Rhonda Allison PUMPKIN E SERUM CELLective Clinical Glycolix Eye Serum Revision Hydrating Serum
Our Price: $38.00
Glycolix Elite Eye Serum
Our Price: $38.50
Rhonda Allison Pumpkin E Serum contains a blend of flavanoids and vital nutrients for much needed support. Ideal for tired, lifeless, dehydrated skin, CELLective Clinical Glycolix Eye Serum is cosmetically
elegant and has been specially formulated for the delicate areas under
the eyes. This nourishing serum formula delivers the hydration benefits
of Hyaluronic Acid resulting in softer, smoother skin under the eyes.
The Glycolix Eye Serum utilizes a rich blend of antioxidants including
Liposomal Vitamins A, C, E, and Green Tea Extract in combination with
Co-Q10, to assist in minimizing free-radical-induced skin damage while
aiding in the restoration of healthy looking skin.
Revision Hydrating Serum formerly known as Hydrating Serum is a very versatile product. Use alone for oily skin or layer with a moisturizer if you have dry skin. Apply this oil-free, lightweight serum after in-office procedures to sooth and hydrate the skin. This product also contains anti-aging properties.
gloTherapeutics Lightening Serum gloTherapeutics Brightening Serum Rhonda Allison NATURALE MEGA BRIGHTENING SERUM
Lightening Serum
Our Price: $42.00
Brightening Serum
Our Price: $44.00
Battles discolorations with a highly effective combination of lighteners, melanin inhibitors and mild exfoliants. Additional ingredients complement the lightening process with benefits that help support the skin's health, strength and brightness.
pH: 3.0
Treats skin discoloration with a full spectrum of natural brighteners and smoothing ingredients to create a fresh glowing complexion. Rhonda Allison Naturale Mega Brightening Serum offers the benefits of natural plant extracts and herbs for serious skin brightening and maintenance are increased by the synergy of this powerful mega complex.
CELLective Rapid Response Line Filler Osmosis REPLENISH Antioxidant Repair Serum gloTherapeutics Pure Hydration
REPLENISH Antioxidant Repair Serum
Our Price: $65.00
Sale Price: $45.50
Savings: $19.50
Pure Hydration
Our Price: $48.00
CELLective Rapid Response Line Filler contains rich concentrations of hyaluronic acid and Vitamin C in filling spheres. These "filling spheres" penetrate the area where applied and literally attract and hold water in the lines and wrinkles plumping them up from the inside.

Osmosis REPLENISH is your antioxidant army with liposomal delivery of the most proven and potent antioxidants available that prevents and fights free radical damage.

has 17 different antioxidants that are delivered to the deeper epidermis where they can effect change and protection to new skin cells.

A lightweight gel that boosts hydration through an infusion of water-binding humectants. Provides a protective moisture reservoir that reduces the effects of dehydration, discourages transepidermal water loss and balances the moisture content
Rhonda Allison MVC SERUM Rhonda Allison Drop of Essence Hydration Drops GlyDerm Intense C Serum PM
Our Price: $54.00
Intense C Serum PM
Our Price: $55.00
Rhonda Allison's MVC Serum has proven to be a thirst quencher for dry, dehydrated skin. Blending essential vitamins (B, C, D, K) with potent building extracts forms a unique skin serum that nourishes, soothes, hydrates, and strengthens. Rhonda Allison Drop of Essence Hydration Drops is a silky, soothing, light serum that quickly penetrates the stratum corneum, providing valuable hydration and tissue support to slow down aging skin.
The composition and molecular structure of Omega 6 essential fatty acids are similar to human lipids and are recommend not only as part of post peel care, but as a daily moisturizer; increasing skin thickness, providing anti-inflammatory benefits
GlyDerm Intense C Serum PM is formulated with 7.5% L-Ascorbic Acid, the only form of vitamin C suitable for topical application.
L-Ascorbic Acid reaches the deepest layers of the skin to provide superior antioxidant protection, defends against damaging UVA and UVB rays, contributes to collagen synthesis and helps prevent premature signs of aging. Intense C Serum PM is a vitamin C concentrate with patented QuSome delivery.
Replenix Power of THREE Serum Rhonda Allison MANDELIC ARGININE SERUM Rhonda Allison RETINOL SUPREME
Power of THREE Serum
Our Price: $79.50
Sale Price: $55.65
Savings: $23.85
Our Price: $58.00
Our Price: $58.00
RepleniX Power of Three SERUM is a lightweight, fast-absorbing formulation in a hyaluronic acid (humectant) base that contains enough green tea extract to equal 500 cups of tea. 90% polyphenol isolates is the active ingredient within the super antioxidant and helps diminish the appearance in fine lines, wrinkles and pores while calming inflammation the skin. Caffeine is also infused within this serum to further the effects of the green tea. Rhonda Allison Mandelic Arginine Serum is a blend of amino acids, antioxidants and AHAs that takes skin through a gentle corrective process. Great for all skin types - it is especially beneficial for photo-aged, sensitive, rosacea-prone, dry blemished skin and and young skin. Rhonda Allison Retinolic Acid has a beneficial exfoliating, restorative effect on skin. This compound adds the perfect balance to strengthen the integrity of the skin.
Replenix Intensive Eye Lightening Serum PCA Anti-Redness Serum Rhonda Allison SHEER TINT FINISHER Tinted Day Cream
Intensive Eye Lightening Serum
Our Price: $85.00
Sale Price: $59.50
Savings: $25.50
Anti-Redness Serum
Our Price: $61.00
New Revolutionary Eye Serum for Dark Circles and Puffiness... RepleniX Intensive Eye Lightening Serum --This specially formulated Eye Serum contains a comprehensive system of peptides, chelators, antioxidants and moisturizers. PCA SKIN Anti-Redness Serum results in a 14% decrease in transepidermal water loss (TEWL) over a four- week period and a 50% reduction in redness over an eight-week period. A healthy choice for skin, Rhonda Allison Tinted Day Cream not only provides a natural equivalent of SPF 18 to protect skin, but moisturizes and protects skin with a hint of color.

Providing potent antioxidants and vital UV protection, this aloe and mineral based day cream forms a safe, soothing emulsion leaving skin protected, refreshed and glowing!
Actifirm Renovation Serum gloTherapeutics Advanced B5 Hydration Rhonda Allison ANTIOXIDANT COMPLEX SERUM
Renovation Serum
Our Price: $71.00
Advanced B5 Hydration
Our Price: $72.00
Our Price: $72.00
Actifirm Renovation Serum is formulated to deliver high concentration of skin firming ingredients to your skin throughout the day. gloTherapeutics Advanced B5 Hydration contains high concentrations of Hyaluronic Acid and Vitamin B5 which naturally provide exceptional nourishment and hydration to the skin while Cromoist CM Glucan protects skin from environmental hazards and oxidative stress in addition to aiding in cell renewal. Rhonda Allison Antioxidant Complex Serum is a firming, toning, strengthening, moisture-binding serum that may be used for all skin types, even blemish-prone skin.
CRS 10% Cell Rejuvenation Serum w/ Growth Factor gloTherapeutics B5 Hydration RepleniX Pure Hydration Hyaluronic Serum
CRS 10% Cell Rejuvenation Serum w/ Growth Factor
Our Price: $103.00
Sale Price: $72.10
Savings: $30.90
B5 Hydration
Our Price: $73.20
tabilized L-Ascorbic Acid in combination with liposome encapsulated TGF-beta-1 growth factor to achieve improvement in skin texture and tone gloTherapeutics B5 Hydration restores skins suppleness through a synergistic balance of nourishment and hydration.
The light hydrating gel with high levels of humectants balances moisture content and prevents transepidermal water loss.
RepleniX Pure Hydration Hyaluronic Serum is a pure, nourishing serum quenches dehydrated skin to impart a supple, smooth complexion and instant correction. This universal booster provides all day moisture retention and visibly reduces the signs of aging with a nourishing blend of antioxidants and humectants. With each drop skin appears brighter, firmer and rejuvenated.
Neostrata Skin Active Antioxidant Defense Serum Citrix CRS 15% Cell Rejuvenation Serum w/ Growth Factor Retriderm Vitamin A Serum
CRS 15% Cell Rejuvenation Serum w/ Growth Factor
Our Price: $112.00
Sale Price: $78.40
Savings: $33.60
Neostrata Skin Active Antioxidant Defense Serum

Boost your daily antiaging regimen with this powerful, concentrated serum formulated to combat oxidation-induced photoaging.

  • 8 powerful, multi-action antioxidants combat oxidative damage and protect the skin from premature aging
  • Bionic and Polyhydroxy Acids help prevent sun-induced cellular damage
  • Citric Acid, Lilac, Green Tea and Chardonnay Grape Seed Extracts work together to neutralize free radicals and help preserve healthy DNA
stabilized L-Ascorbic Acid in combination with liposome encapsulated TGF-beta-1 growth factor to achieve improvement in skin texture and tone The visible reconditioning results provided by Retriderm Vitamin A Serum can be attributed to its high concentration of retinol. The topical application of Vitamin A (retinol) quickly promotes a clearer overall complexion by inciting the growth of new skin cells, which provide greater structural integrity for your skin.
Sircuit infusion-A intensive retinoid serum Pevonia RS2 Concentrate NIA 24 Rapid Depigmentation Serum
RS2 Concentrate
Our Price: $80.00
Sircuit Cosmeceuticals infusion-A intensive retinoid serum is formulated with extremely potent anti-aging, nourishing, protective and skin supporting ingredients. The most important being patent pending IconicA. IconicA contains skin perfecting stabilized retinaldehyde making it much more potent than traditional retinaldehyde. Pevonia RS2 Concentrate is specially formulated for rosacea prone skin and sensitive skin. Delivers immediate cooling, strengthens capillaries and controls blotchiness.


Get rid of age spots fast with NIA24 Rapid Depigmentation Serum.

See a significant improvement in your complexion with this NIA24 treatment for hyperpigmentation. NIA 24 Rapid Depigmentation Serum contains a mix of concentrated, clinically proven ingredients that improve skins tone and texture while it fades age spots. This lightweight serum penetrates into the deep layers of your skin, effectively targeting the signs of hyperpigmentation at the source. With continued use, you will quickly notice a brighter, clearer complexion with fewer age spots.